Small molecules which mimic Rosiglitazone treatment
Canned Analysis
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General Information
AccessionDCA00012228
TitleSmall molecules which mimic Rosiglitazone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Rosiglitazone treatment in the diabetes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e1f3e467bea600fb9488
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2815
Cell Typediabetes
Drug NameRosiglitazone
DrugBank IDDB00412
Organismmouse
SMILES IDO=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM286169, GSM286173, GSM286176, GSM286178, GSM286430
Perturbed SamplesGSM286437, GSM286438, GSM286591, GSM286592, GSM286593
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11343
Gene Expression Omnibus
Rosiglitazone effect on streptozotocin-induced diabetic DBA/2J mice: perpheral sciatic nerve
26
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