Small molecules which reverse Paclitaxel treatment
Canned Analysis
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General Information
AccessionDCA00012261
TitleSmall molecules which reverse Paclitaxel treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Paclitaxel treatment in the paclitaxel-resistant MDA-MB-231 cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e276e467bea600fb94c2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3238
Cell Typepaclitaxel-resistant MDA-MB-231 cancer cells
Drug NamePaclitaxel
DrugBank IDDB01229
Organismhuman
PubChem CID36314
SMILES IDCC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM320838, GSM320842, GSM320846, GSM320850
Perturbed SamplesGSM320839, GSM320843, GSM320847, GSM320851
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12791
Gene Expression Omnibus
Acquired paclitaxel-resistant MDA-MB-231 cancer cells response to bexarotene treatment
14
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