Small molecules which reverse Bortezomib treatment
Canned Analysis
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General Information
AccessionDCA00012265
TitleSmall molecules which reverse Bortezomib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Bortezomib treatment.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e66de467bea600fb967e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2686
Drug NameBortezomib
DrugBank IDDB00188
Organismhuman
SMILES IDCC(C[C@@H](B(O)O)NC(=O)[C@@H](NC(=O)c1cnccn1)Cc1ccccc1)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM766676, GSM766677, GSM766678
Perturbed SamplesGSM766682, GSM766683, GSM766684
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE30931
Gene Expression Omnibus
Proteasome inhibitor Bortezomib effect on MCF7 breast cancer cells
7
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