Small molecules which reverse Dactinomycin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00012283
TitleSmall molecules which reverse Dactinomycin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Dactinomycin treatment in the wild type cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e010e467bea600fb93b2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2700
Cell Typewild type
Drug NameDactinomycin
DrugBank IDDB00970
Organismmouse
SMILES IDO=C1N[C@H](C(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)N([C@H](C(=O)O[C@@H]([C@@H]1NC(=O)c1c2nc3c(ccc(c3oc2c(c(=O)c1N)C)C)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C(=O)[C@H]2N(C(=O)[C@H](NC1=O)C(C)C)CCC2)C)C)C(C)C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM120234, GSM120244, GSM120254, GSM120263, GSM120272
Perturbed SamplesGSM120236, GSM120246, GSM120256, GSM120265, GSM120274
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5324
Gene Expression Omnibus
Tristetrapolin-deficiency and mRNA decay in fibroblasts: time course
21
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.