Small molecules which mimic Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00012330
TitleSmall molecules which mimic Estradiol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Estradiol treatment in the MCF7/BUS human breast cancer cells - 60 pM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d56ee467bea600fb8efc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3063
Cell TypeMCF7/BUS human breast cancer cells - 60 pM
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM105292, GSM105293, GSM105294, GSM105295, GSM105296
Perturbed SamplesGSM105307, GSM105308, GSM105309, GSM105310, GSM105311
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE4668
Gene Expression Omnibus
Low concentrations of 17beta-estradiol effect on breast cancer cell line
28
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