Small molecules which reverse Estradiol treatment
Canned Analysis
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General Information
AccessionDCA00012341
TitleSmall molecules which reverse Estradiol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Estradiol treatment in the MCF7 cells depleted of ERK1 - 4 Hours after treatment cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dafde467bea600fb9176
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3344
Cell TypeMCF7 cells depleted of ERK1 - 4 Hours after treatment
Drug NameEstradiol
DrugBank IDDB00783
Organismhuman
PubChem CID5757
SMILES IDCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM606119, GSM606120, GSM606121
Perturbed SamplesGSM606122, GSM606123, GSM606124
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24592
Gene Expression Omnibus
Estradiol effect on ERK1/ERK2-deficient MCF-7 breast adenocarcinoma cells: time course
42
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