Small molecules which reverse Imatinib treatment
Canned Analysis
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General Information
AccessionDCA00012377
TitleSmall molecules which reverse Imatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Imatinib treatment.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d279e467bea600fb8dae
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2763
Drug NameImatinib
DrugBank IDDB00619
Organismhuman
PubChem CID5291
SMILES IDCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM577857, GSM577859, GSM577861, GSM577863
Perturbed SamplesGSM577858, GSM577860, GSM577862, GSM577913
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23743
Gene Expression Omnibus
Imatinib effect on Philadelphia chromosome positive acute lymphoblastic leukemia cells
7
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