Small molecules which reverse Irinotecan treatment
Canned Analysis
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General Information
AccessionDCA00012381
TitleSmall molecules which reverse Irinotecan treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Irinotecan treatment in the stomach cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d8c9e467bea600fb907e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2767
Cell Typestomach
Drug NameIrinotecan
DrugBank IDDB00762
Organismrat
PubChem CID60838
SMILES IDCCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM297524, GSM297525
Perturbed SamplesGSM297526, GSM297527
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11722
Gene Expression Omnibus
Gastrointestinal tract response to cytotoxic chemotherapy: time course
21
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