Small molecules which mimic Irinotecan treatment
Canned Analysis
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General Information
AccessionDCA00012384
TitleSmall molecules which mimic Irinotecan treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Irinotecan treatment.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d7ade467bea600fb8ffc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2769
Drug NameIrinotecan
DrugBank IDDB00762
Organismrat
PubChem CID60838
SMILES IDCCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC(=O)N6CCC(CC6)N7CCCCC7
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM297544, GSM297545
Perturbed SamplesGSM297546, GSM297547
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11722
Gene Expression Omnibus
Gastrointestinal tract response to cytotoxic chemotherapy: time course
21
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