Small molecules which reverse Pioglitazone treatment
Canned Analysis
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General Information
AccessionDCA00012421
TitleSmall molecules which reverse Pioglitazone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Pioglitazone treatment in the 3 months cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e25ae467bea600fb94b6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2795
Cell Type3 months
Drug NamePioglitazone
DrugBank IDDB01132
Organismrat
PubChem CID4829
SMILES IDCCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM506974, GSM506975, GSM506976, GSM506977, GSM506978, GSM506979, GSM506980, GSM506981
Perturbed SamplesGSM506982, GSM506983, GSM506984, GSM506985, GSM506986, GSM506987, GSM506988, GSM506989
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20219
Gene Expression Omnibus
Thiazolidinedione pioglitazone effect on Fischer 344 model of aging: hippocampus
14
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