Small molecules which reverse Tretinoin treatment
Canned Analysis
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General Information
AccessionDCA00012455
TitleSmall molecules which reverse Tretinoin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Tretinoin treatment in the NB4 APL 9 acute promyelocytic leukemia cells - (TG2-knockdown) 72 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d118e467bea600fb8d16
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3232
Cell TypeNB4 APL 9 acute promyelocytic leukemia cells - (TG2-knockdown) 72 Hours
Drug NameTretinoin
DrugBank IDDB00755
Organismhuman
PubChem CID444795
SMILES IDCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM594070, GSM594071, GSM594072
Perturbed SamplesGSM594082, GSM594083, GSM594084
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23702
Gene Expression Omnibus
All-trans-retinoic acid effect on transglutaminase 2-silenced, NB4 model of acute promyelocytic leukemia: time course
49
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