Small molecules which mimic Torcetrapib treatment
Canned Analysis
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General Information
AccessionDCA00012486
TitleSmall molecules which mimic Torcetrapib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Torcetrapib treatment in the H295R cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d445e467bea600fb8e78
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDdrug:3172
Cell TypeH295R cells
Drug NameTorcetrapib
Organismhuman
PubChem CID159325
SMILES IDCCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM399572, GSM399573, GSM399574
Perturbed SamplesGSM399575, GSM399576, GSM399577, GSM399578, GSM399579, GSM399580
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15918
Gene Expression Omnibus
Torcetrapib effect on adrenal carcinoma cell line
14
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