Small molecules which mimic Doxycycline treatment
Canned Analysis
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General Information
AccessionDCA00012496
TitleSmall molecules which mimic Doxycycline treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Doxycycline treatment in the RT112 cancer cell line (FGFR3 knocked down with shRNA 6-16) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e966e467bea600fb97ca
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3041
Cell TypeRT112 cancer cell line (FGFR3 knocked down with shRNA 6-16)
Drug NameDoxycycline
DrugBank IDDB00254
Organismhuman
PubChem CID5281011
SMILES IDCC1C2C(C3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1007032, GSM1007033, GSM1007046
Perturbed SamplesGSM1007041, GSM1007042, GSM1007055
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41035
Gene Expression Omnibus
Fibroblast growth factor receptor 3 depletion effect on bladder cancer cell line RT112
85
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