Small molecules which reverse Triiodothyronine-[13c6] hydrochloride (t3 thyronine) treatment
Canned Analysis
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General Information
AccessionDCA00012499
TitleSmall molecules which reverse Triiodothyronine-[13c6] hydrochloride (t3 thyronine) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Triiodothyronine-[13c6] hydrochloride (t3 thyronine) treatment in the HepG3 cell line (THRA wild type) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e973e467bea600fb97d0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3042
Cell TypeHepG3 cell line (THRA wild type)
Drug NameTriiodothyronine-[13c6] hydrochloride (t3 thyronine)
Organismhuman
PubChem CID53442265
SMILES IDC1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O.Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM721654, GSM721655, GSM721656
Perturbed SamplesGSM721657, GSM721658, GSM721659
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29159
Gene Expression Omnibus
Renal clear cell carcinoma-thyroid hormone receptor mutants: HepG3 cell line
70
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