Small molecules which reverse Diclofenac treatment
Canned Analysis
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General Information
AccessionDCA00012521
TitleSmall molecules which reverse Diclofenac treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Diclofenac treatment in the liver cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e791e467bea600fb96fe
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDdrug:3053
Cell Typeliver
Drug NameDiclofenac
DrugBank IDDB00586
Organismhuman
PubChem CID3033
SMILES IDC1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1311186, GSM1311188, GSM1311190, GSM1311192, GSM1311194
Perturbed SamplesGSM1311187, GSM1311189, GSM1311191, GSM1311193, GSM1311195
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE54255
Gene Expression Omnibus
Gene expression data from precision cut human liver slices treated to diclofenac
7
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