Small molecules which reverse Diclofenac treatment
Canned Analysis
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General Information
AccessionDCA00012525
TitleSmall molecules which reverse Diclofenac treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Diclofenac treatment in the THP-1 acute monocytic leukemia cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e788e467bea600fb96fa
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDdrug:3057
Cell TypeTHP-1 acute monocytic leukemia cells
Drug NameDiclofenac
DrugBank IDDB00586
Organismhuman
PubChem CID3033
SMILES IDC1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM697694, GSM697695
Perturbed SamplesGSM697698, GSM697699
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28185
Gene Expression Omnibus
The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells t...
14
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