Small molecules which mimic Diclofenac treatment
Canned Analysis
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General Information
AccessionDCA00012526
TitleSmall molecules which mimic Diclofenac treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Diclofenac treatment in the HL60 promyelocytic leukemia cell line cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d2c6e467bea600fb8dd0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDdrug:3058
Cell TypeHL60 promyelocytic leukemia cell line
Drug NameDiclofenac
DrugBank IDDB00586
Organismhuman
PubChem CID3033
SMILES IDC1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM697692, GSM697693
Perturbed SamplesGSM697696, GSM697697
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE28185
Gene Expression Omnibus
The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells t...
14
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