Small molecules which reverse Nicotine treatment
Canned Analysis
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General Information
AccessionDCA00012529
TitleSmall molecules which reverse Nicotine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Nicotine treatment in the lymphoblast cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e56fe467bea600fb9612
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorjustinenoel
CREEDS IDdrug:3064
Cell Typelymphoblast
Drug NameNicotine
DrugBank IDDB00184
Organismhuman
PubChem CID942
SMILES IDCN1CCCC1C2=CN=CC=C2
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM144122, GSM144123, GSM144124, GSM144125, GSM144126, GSM144127, GSM144128, GSM144129, GSM144130
Perturbed SamplesGSM144131, GSM144132, GSM144133, GSM144134, GSM144135, GSM144136
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6264
Gene Expression Omnibus
Transcriptional profiling of tobacco smokers versus controls
12
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