Small molecules which mimic 4-hydroxynonenal treatment
Canned Analysis
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General Information
AccessionDCA00012562
TitleSmall molecules which mimic 4-hydroxynonenal treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by 4-hydroxynonenal treatment in the RKO colorectal carcinoma cell line (24 Hours after exposure to 20uM) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e4d3e467bea600fb95cc
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3081
Cell TypeRKO colorectal carcinoma cell line (24 Hours after exposure to 20uM)
Drug Name4-hydroxynonenal
Organismhuman
PubChem CID5283344
SMILES IDCCCCCC(C=CC=O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM45086, GSM45100, GSM45112
Perturbed SamplesGSM45088, GSM45104, GSM45114
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2397
Gene Expression Omnibus
Lipid peroxidation product 4-hydroxy-2-nonenal effect on cells: time course
42
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