Small molecules which reverse Cisplatin treatment
Canned Analysis
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General Information
AccessionDCA00012583
TitleSmall molecules which reverse Cisplatin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Cisplatin treatment in the NCI-H460 human lung large cell carcinoma cell line - 2 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e306e467bea600fb9502
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3095
Cell TypeNCI-H460 human lung large cell carcinoma cell line - 2 Hours
Drug NameCisplatin
DrugBank IDDB00515
Organismhuman
PubChem CID441203
SMILES IDN.N.Cl[Pt+2]Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1034057, GSM1034058, GSM1034059
Perturbed SamplesGSM1034075, GSM1034076, GSM1034077
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE42172
Gene Expression Omnibus
Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on gene expression in the NCI-H460 human lung large cell carcinoma ce...
14
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