Small molecules which mimic Letrozole treatment
Canned Analysis
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General Information
AccessionDCA00012586
TitleSmall molecules which mimic Letrozole treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Letrozole treatment in the breast cancer biopsies cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e2f1e467bea600fb94f8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDdrug:3097
Cell Typebreast cancer biopsies
Drug NameLetrozole
DrugBank IDDB01006
Organismhuman
PubChem CID3902
SMILES IDC1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM125123, GSM125125, GSM125127, GSM125129, GSM125131, GSM125133, GSM125135, GSM125137, GSM125139, GSM125141, GSM125143, GSM125145, GSM125147, GSM125149, GSM125151, GSM125153, GSM125155, GSM125157, GSM125159, GSM125161, GSM125163, GSM125165, GSM125167, GS
Perturbed SamplesGSM125124, GSM125126, GSM125128, GSM125130, GSM125132, GSM125134, GSM125136, GSM125138, GSM125140, GSM125142, GSM125144, GSM125146, GSM125148, GSM125150, GSM125152, GSM125154, GSM125156, GSM125158, GSM125160, GSM125162, GSM125164, GSM125166, GSM125168, GS
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5462
Gene Expression Omnibus
Letrozole effect on breast cancer tumors
7
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