Small molecules which reverse Rosiglitazone treatment
Canned Analysis
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General Information
AccessionDCA00012595
TitleSmall molecules which reverse Rosiglitazone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Rosiglitazone treatment in the hearts from obese diabetic C57BL/KsJ-db/db mice cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eaf8e467bea600fb9878
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorjustinenoel
CREEDS IDdrug:3100
Cell Typehearts from obese diabetic C57BL/KsJ-db/db mice
Drug NameRosiglitazone
Organismmouse
PubChem CID77999
SMILES IDCN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM904679, GSM904680, GSM904681, GSM904682, GSM904683
Perturbed SamplesGSM904684, GSM904685, GSM904686, GSM904687, GSM904688
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36875
Gene Expression Omnibus
Diabetic db/db heart response to rosiglitazone
7
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