Small molecules which mimic Bleomycin treatment
Canned Analysis
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General Information
AccessionDCA00012602
TitleSmall molecules which mimic Bleomycin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Bleomycin treatment in the LUNG (wild type) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eaace467bea600fb9856
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3104
Cell TypeLUNG (wild type)
Drug NameBleomycin
DrugBank IDDB00290
Organismmouse
PubChem CID5360373
SMILES IDCC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1068446, GSM1068447, GSM1068448
Perturbed SamplesGSM1068449, GSM1068450, GSM1068451
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE43695
Gene Expression Omnibus
Fra-1 deficient lung response to fibrotic agent bleomycin
33
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