Small molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00012613
TitleSmall molecules which reverse 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the Hypothalamus (postnatal day70 male rats exposed in utero to dioxin at gestational day15) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d8bfe467bea600fb9078
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3111
Cell TypeHypothalamus (postnatal day70 male rats exposed in utero to dioxin at gestational day15)
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismrat
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1168492, GSM1168493, GSM1168494
Perturbed SamplesGSM1168495, GSM1168496, GSM1168497
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48100
Gene Expression Omnibus
Dioxin exposure in utero effect on the hypothalamus at maturity
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.