Small molecules which mimic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00012614
TitleSmall molecules which mimic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the Pituitary gland (postnatal day70 male rats exposed in utero to dioxin at gestational day15) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e1fce467bea600fb948c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3112
Cell TypePituitary gland (postnatal day70 male rats exposed in utero to dioxin at gestational day15)
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismrat
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1168486, GSM1168487, GSM1168488
Perturbed SamplesGSM1168489, GSM1168490, GSM1168491
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48100
Gene Expression Omnibus
Dioxin exposure in utero effect on the hypothalamus at maturity
14
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