Small molecules which reverse Neocarzinostatin treatment
Canned Analysis
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General Information
AccessionDCA00012617
TitleSmall molecules which reverse Neocarzinostatin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Neocarzinostatin treatment in the HEK293 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e8dde467bea600fb9790
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDdrug:3113
Cell TypeHEK293
Drug NameNeocarzinostatin
Organismhuman
PubChem CID5282473
SMILES IDCC1C(C(C(C(O1)OC2C3CC#CC4C(O4)(C#CC3=CC2OC(=O)C5=C(C=CC6=C(C=C(C=C65)OC)C)O)C7COC(=O)O7)NC)O)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM28627, GSM28628, GSM28629
Perturbed SamplesGSM28630, GSM28631, GSM28632
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE1676
Gene Expression Omnibus
siRNA knockdown and transcriptional response to DNA damage
35
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