Small molecules which reverse Bleomycin treatment
Canned Analysis
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General Information
AccessionDCA00012637
TitleSmall molecules which reverse Bleomycin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Bleomycin treatment in the Lung (FIZZ2 deficient) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dbd3e467bea600fb91d6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3122
Cell TypeLung (FIZZ2 deficient)
Drug NameBleomycin
DrugBank IDDB00290
Organismmouse
PubChem CID5360373
SMILES IDCC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM629997, GSM629998, GSM629999
Perturbed SamplesGSM630000, GSM630001, GSM630002
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE25640
Gene Expression Omnibus
FIZZ2 deficient lung response to the fibrotic agent bleomycin
28
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