Small molecules which reverse Pertuzumab treatment
Canned Analysis
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General Information
AccessionDCA00012641
TitleSmall molecules which reverse Pertuzumab treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Pertuzumab treatment in the SKOV3 ovarian cancer xenograft tumor cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dc01e467bea600fb91ea
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3124
Cell TypeSKOV3 ovarian cancer xenograft tumor
Drug NamePertuzumab
DrugBank IDDB06366
Organismhuman
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM780707, GSM780708, GSM780709, GSM780719, GSM780720, GSM780721
Perturbed SamplesGSM780713, GSM780714, GSM780715, GSM780725, GSM780726, GSM780727
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE31432
Gene Expression Omnibus
Ovarian cancer xenograft tumor response to trastuzumab and pertuzumab
14
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