Small molecules which mimic Motexafin gadolinium (4 h) treatment
Canned Analysis
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General Information
AccessionDCA00012642
TitleSmall molecules which mimic Motexafin gadolinium (4 h) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Motexafin gadolinium (4 h) treatment in the A549 cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dbf5e467bea600fb91e4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDdrug:3125
Cell TypeA549
Drug NameMotexafin gadolinium (4 h)
DrugBank IDDB05428
Organismhuman
SMILES ID[O-]C(=O)C.[O-]C(=O)C.OCCCC1=C(C)/C/2=C/N=c/3\cc(OCCOCCOCCOC)c(c\c3=N/C=C/3\N=C(/C=c/4\[n-]/c(=C\C1=N2)/c(CC)c4CC)C(=C3C)CCCO)OCCOCCOCCOC.[Gd+3]
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM39804, GSM39805, GSM39806
Perturbed SamplesGSM39801, GSM39802, GSM39803
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE2189
Gene Expression Omnibus
Lung cancer cell line response to motexafin gadolinium: time course
7
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