Small molecules which reverse Calcitriol treatment
Canned Analysis
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General Information
AccessionDCA00012647
TitleSmall molecules which reverse Calcitriol treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Calcitriol treatment in the Mtb H37Rv-infected THP-1 macrophages cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d4dae467bea600fb8eba
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3129
Cell TypeMtb H37Rv-infected THP-1 macrophages
Drug NameCalcitriol
Organismhuman
PubChem CID5280453
SMILES IDCC(CCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1276666, GSM1276667, GSM1276668
Perturbed SamplesGSM1276669, GSM1276670, GSM1276671
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52819
Gene Expression Omnibus
Mycobacterium tuberculosis H37Rv-infected macrophages response to vitamin D
14
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