Small molecules which mimic Cetuximab treatment
Canned Analysis
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General Information
AccessionDCA00012652
TitleSmall molecules which mimic Cetuximab treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Cetuximab treatment in the CAL27 squamous cell carcinoma (HNSCC) cell line - (15nM for 13 hours) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1ecf8e467bea600fb995e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3133
Cell TypeCAL27 squamous cell carcinoma (HNSCC) cell line - (15nM for 13 hours)
Drug NameCetuximab
DrugBank IDDB00002
Organismhuman
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1506255, GSM1506256, GSM1506257
Perturbed SamplesGSM1506252, GSM1506253, GSM1506254
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE61495
Gene Expression Omnibus
Overcoming cetuximab resistance in HNSCC: The role of AURKB and DUSP proteins
28
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