Small molecules which reverse Tretinoin treatment
Canned Analysis
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General Information
AccessionDCA00012663
TitleSmall molecules which reverse Tretinoin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Tretinoin treatment in the ME180 squamous cell carcinoma cell line - 3 hours 10μM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d6cbe467bea600fb8f96
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3140
Cell TypeME180 squamous cell carcinoma cell line - 3 hours 10μM
Drug NameTretinoin
DrugBank IDDB00755
Organismhuman
PubChem CID444795
SMILES IDCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1315852, GSM1315853, GSM1315854, GSM1315855
Perturbed SamplesGSM1315860, GSM1315861, GSM1315862, GSM1315863
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54464
Gene Expression Omnibus
All-trans retinoic acid effect on the squamous cell carcinoma cell line ME180: time course
21
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