Small molecules which mimic Tretinoin treatment
Canned Analysis
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General Information
AccessionDCA00012664
TitleSmall molecules which mimic Tretinoin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Tretinoin treatment in the ME180 squamous cell carcinoma cell line - 6 hours 10μM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1de64e467bea600fb92f8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3141
Cell TypeME180 squamous cell carcinoma cell line - 6 hours 10μM
Drug NameTretinoin
DrugBank IDDB00755
Organismhuman
PubChem CID444795
SMILES IDCC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1315852, GSM1315853, GSM1315854, GSM1315855
Perturbed SamplesGSM1315864, GSM1315865, GSM1315866, GSM1315867
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54464
Gene Expression Omnibus
All-trans retinoic acid effect on the squamous cell carcinoma cell line ME180: time course
21
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