Small molecules which mimic Doxorubicin treatment
Canned Analysis
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General Information
AccessionDCA00012712
TitleSmall molecules which mimic Doxorubicin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Doxorubicin treatment in the SCC25 tongue epidermal keratinocyte cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e8e4e467bea600fb9792
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3179
Cell TypeSCC25 tongue epidermal keratinocyte
Drug NameDoxorubicin
DrugBank IDDB00997
Organismhuman
PubChem CID31703
SMILES IDCC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1400402, GSM1400403
Perturbed SamplesGSM1400404, GSM1400405
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE58074
Gene Expression Omnibus
Identifying the downstream effectors of E2F7 in squamous cell carcinoma (SCC) cells
14
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