Small molecules which mimic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
Canned Analysis
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General Information
AccessionDCA00012732
TitleSmall molecules which mimic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment in the Hematopoietic CD34+ cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e7c6e467bea600fb9714
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3189
Cell TypeHematopoietic CD34+ cells
Drug Name2,3,7,8-tetrachlorodibenzo-p-dioxin
Organismhuman
PubChem CID10852289
SMILES IDCC(C)C=CC(=O)ONC(=O)COC1=CC=C(C=C1)[N+](=O)[O-]
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM595118, GSM595120, GSM595122, GSM595124
Perturbed SamplesGSM595119, GSM595121, GSM595123, GSM595125
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE24193
Gene Expression Omnibus
Hematopoietic CD34+ cells exposed in vitro to dioxin
7
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