Small molecules which reverse Mk-886 treatment
Canned Analysis
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General Information
AccessionDCA00012737
TitleSmall molecules which reverse Mk-886 treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Mk-886 treatment in the A549 cell line (lung cancer) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e9eae467bea600fb9804
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDdrug:3193
Cell TypeA549 cell line (lung cancer)
Drug NameMk-886
Organismhuman
PubChem CID3651377
SMILES IDCC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM75009, GSM75010, GSM75013, GSM75015
Perturbed SamplesGSM75011, GSM75012, GSM75014, GSM75016
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3202
Gene Expression Omnibus
MK886 treatment of H720 non-small cell lung cancer cell line
14
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