Small molecules which mimic Mesalazine treatment
Canned Analysis
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General Information
AccessionDCA00012742
TitleSmall molecules which mimic Mesalazine treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Mesalazine treatment in the colon cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1dcbbe467bea600fb923c
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgaribr01
CREEDS IDdrug:3289
Cell Typecolon
Drug NameMesalazine
DrugBank IDDB00244
Organismhuman
PubChem CID4075
SMILES IDC1=CC(=C(C=C1N)C(=O)O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM948552, GSM948553, GSM948554, GSM948555, GSM948556, GSM948557, GSM948558, GSM948559, GSM948560
Perturbed SamplesGSM948567, GSM948568, GSM948570, GSM948572, GSM948577, GSM948578, GSM948581, GSM948582, GSM948588
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38713
Gene Expression Omnibus
Intestinal mucosa response to active and inactive ulcerative colitis: colon biopsies
28
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