Small molecules which mimic Atorvastatin treatment
Canned Analysis
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General Information
AccessionDCA00012744
TitleSmall molecules which mimic Atorvastatin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Atorvastatin treatment in the Peripheral blood monocytes cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e9cbe467bea600fb97f6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3196
Cell TypePeripheral blood monocytes
Drug NameAtorvastatin
DrugBank IDDB01076
Organismhuman
SMILES IDOC(CC(CC(=O)[O-])O)CCn1c(C(C)C)c(c(c1c1ccc(cc1)F)c1ccccc1)C(=O)Nc1ccccc1
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM287667, GSM287668, GSM287669
Perturbed SamplesGSM287670, GSM287671, GSM287672
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE11393
Gene Expression Omnibus
Atorvastatin treatment of familial combined hyperlipidemia: peripheral blood monocytes
28
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