Small molecules which reverse Testosterone treatment
Canned Analysis
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General Information
AccessionDCA00012767
TitleSmall molecules which reverse Testosterone treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Testosterone treatment in the Skeletal muscles (of HIV-infected males) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1edf3e467bea600fb99d0
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3206
Cell TypeSkeletal muscles (of HIV-infected males)
Drug NameTestosterone
DrugBank IDDB00624
Organismhuman
PubChem CID6013
SMILES IDCC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM113921, GSM115323, GSM115325, GSM115326, GSM115327, GSM115328, GSM115329, GSM115330, GSM115331
Perturbed SamplesGSM115332, GSM115333, GSM115334, GSM115335, GSM115336, GSM115337, GSM115338, GSM115339, GSM115340, GSM115341
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE5106
Gene Expression Omnibus
Testosterone effect on skeletal muscles of HIV-infected males experiencing weight loss
7
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