Small molecules which reverse Lysophosphatidic acid treatment
Canned Analysis
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General Information
AccessionDCA00012793
TitleSmall molecules which reverse Lysophosphatidic acid treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Lysophosphatidic acid treatment in the AGS gastric adenocarcinoma cells (NET1 knockdown - 65shRNA) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d3c0e467bea600fb8e3e
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3225
Cell TypeAGS gastric adenocarcinoma cells (NET1 knockdown - 65shRNA)
Drug NameLysophosphatidic acid
Organismhuman
PubChem CID3988
SMILES IDCCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM646073, GSM646074
Perturbed SamplesGSM646067, GSM646068
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26309
Gene Expression Omnibus
Lysophosphatidic acid effect on RhoA GEF Exchange Factor NET1-deficient, AGS gastric adenocarcinoma cells
49
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