Small molecules which mimic Thapsigargin treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00012804
TitleSmall molecules which mimic Thapsigargin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Thapsigargin treatment in the Immortalized B cells (from MZ twin pairs - African American ancestry) cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d846e467bea600fb9040
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3236
Cell TypeImmortalized B cells (from MZ twin pairs - African American ancestry)
Drug NameThapsigargin
Organismhuman
PubChem CID446378
SMILES IDCCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM494452, GSM494454, GSM494456, GSM494458, GSM494460, GSM494462, GSM494464, GSM494466, GSM494468, GSM494470, GSM494472, GSM494474, GSM494476, GSM494478, GSM494480, GSM494482, GSM494484, GSM494486, GSM494488, GSM494490, GSM494492, GSM494494, GSM494496, GS
Perturbed SamplesGSM494453, GSM494455, GSM494457, GSM494459, GSM494461, GSM494463, GSM494465, GSM494467, GSM494469, GSM494471, GSM494473, GSM494475, GSM494477, GSM494479, GSM494481, GSM494483, GSM494485, GSM494487, GSM494489, GSM494491, GSM494493, GSM494495, GSM494497, GS
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19519
Gene Expression Omnibus
Endoplasmic reticulum stress effect on lymphoblastoid cells of monozygotic twins
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.