Small molecules which reverse 4-hydroxytamoxifen treatment
Canned Analysis
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General Information
AccessionDCA00012809
TitleSmall molecules which reverse 4-hydroxytamoxifen treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by 4-hydroxytamoxifen treatment in the MCF7 breast cancer cells - 100nM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d163e467bea600fb8d36
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3239
Cell TypeMCF7 breast cancer cells - 100nM
Drug Name4-hydroxytamoxifen
Organismhuman
PubChem CID449459
SMILES IDCCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM645710, GSM645711, GSM645718, GSM645719
Perturbed SamplesGSM645712, GSM645713
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26298
Gene Expression Omnibus
Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells
21
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