Small molecules which mimic Plx4720 treatment
Canned Analysis
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General Information
AccessionDCA00012814
TitleSmall molecules which mimic Plx4720 treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Plx4720 treatment in the HT29 and Colo205 parental colorectal cancer (CRC) cell lines cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d55ce467bea600fb8ef4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorPascal
CREEDS IDdrug:3243
Cell TypeHT29 and Colo205 parental colorectal cancer (CRC) cell lines
Drug NamePlx4720
Organismhuman
PubChem CID24180719
SMILES IDCCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM846889, GSM846891
Perturbed SamplesGSM846890, GSM846892
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE34299
Gene Expression Omnibus
Colon cancer cell lines with acquired resistance to BRAF inhibitor
12
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