Small molecules which reverse Nvp-tnks656 (tankyrase inhibitor) treatment
Canned Analysis
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General Information
AccessionDCA00012819
TitleSmall molecules which reverse Nvp-tnks656 (tankyrase inhibitor) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Nvp-tnks656 (tankyrase inhibitor) treatment in the SW480 cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e526e467bea600fb95f2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorPascal
CREEDS IDdrug:3247
Cell TypeSW480 cancer cells
Drug NameNvp-tnks656 (tankyrase inhibitor)
Organismhuman
PubChem CID71227201
SMILES IDCOC1=CC=C(C=C1)C(=O)C2CCN(CC2)CC(=O)N(CC3CC3)CC4=NC(=O)C5=C(N4)CCOC5
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1340521, GSM1340522
Perturbed SamplesGSM1340525, GSM1340526
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55624
Gene Expression Omnibus
SW480 KRAS-mutant colorectal cancer cell line response to dual inhibition of tankyrase and MEK: time course
48
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