Small molecules which mimic Mek inhibitor (meki : azd6244) treatment
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00012822
TitleSmall molecules which mimic Mek inhibitor (meki : azd6244) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Mek inhibitor (meki : azd6244) treatment in the SW480 cancer cells cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e658e467bea600fb9674
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorPascal
CREEDS IDdrug:3250
Cell TypeSW480 cancer cells
Drug NameMek inhibitor (meki : azd6244)
Organismhuman
PubChem CID10127622
SMILES IDCN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM1340521, GSM1340522
Perturbed SamplesGSM1340527, GSM1340528
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55624
Gene Expression Omnibus
SW480 KRAS-mutant colorectal cancer cell line response to dual inhibition of tankyrase and MEK: time course
48
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.