Small molecules which reverse Phorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa) treatment
Canned Analysis
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General Information
AccessionDCA00012829
TitleSmall molecules which reverse Phorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa) treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Phorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa) treatment in the dorsal skin cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e688e467bea600fb968a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorPascal
CREEDS IDdrug:3256
Cell Typedorsal skin
Drug NamePhorbol ester 12-o-tetradecanoylphorbol-13-acetate (tpa)
Organismmouse
PubChem CID27924
SMILES IDCCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1003251, GSM1003252, GSM1003253
Perturbed SamplesGSM1003248, GSM1003249, GSM1003250
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40849
Gene Expression Omnibus
Phorbol ester effect on skin of Rho exchange factor Vav2/Vav3 double knockout mutants: time course
7
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