Small molecules which mimic Curcumin treatment
Canned Analysis
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General Information
AccessionDCA00012834
TitleSmall molecules which mimic Curcumin treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Curcumin treatment in the U937 monoctyes exposed to oxidative stress - 4 Hours cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1d347e467bea600fb8e08
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3407
Cell TypeU937 monoctyes exposed to oxidative stress - 4 Hours
Drug NameCurcumin
Organismhuman
PubChem CID969516
SMILES IDCOC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM276211, GSM276219, GSM276227
Perturbed SamplesGSM276212, GSM276220, GSM276228
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE10896
Gene Expression Omnibus
Curcumin effect on oxidatively stressed monocyte cell line: time course
28
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