Small molecules which mimic Nickel chloride treatment
Canned Analysis
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General Information
AccessionDCA00012896
TitleSmall molecules which mimic Nickel chloride treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which mimic the gene expression signature induced by Nickel chloride treatment in the H4-II-E-C3 LIVER-derived cell line - 400 uM cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1e76ae467bea600fb96ec
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDdrug:3278
Cell TypeH4-II-E-C3 LIVER-derived cell line - 400 uM
Drug NameNickel chloride
Organismrat
PubChem CID24385
SMILES IDCl[Ni]Cl
L1000CDS2 parameters
Directionmimic
Characteristic Direction parameters
Control SamplesGSM782280, GSM782281, GSM782291, GSM782292, GSM782302, GSM782303, GSM782313, GSM782314
Perturbed SamplesGSM782284, GSM782295, GSM782306, GSM782317
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE31503
Gene Expression Omnibus
Heavy metal effect on liver derived cell line H4-II-E-C3
56
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