Small molecules which reverse Dasatinib treatment
Canned Analysis
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General Information
AccessionDCA00012945
TitleSmall molecules which reverse Dasatinib treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Dasatinib treatment in the Pancreatic Cancer Cell Lines cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1da89e467bea600fb9142
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3306
Cell TypePancreatic Cancer Cell Lines
Drug NameDasatinib
DrugBank IDDB01254
Organismhuman
PubChem CID3062316
SMILES IDCC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1435693, GSM1435694, GSM1435695, GSM1435696, GSM1435697, GSM1435698, GSM1435699, GSM1435700, GSM1435701
Perturbed SamplesGSM1435684, GSM1435685, GSM1435686, GSM1435687, GSM1435688, GSM1435689, GSM1435690, GSM1435691, GSM1435692
Tools used in the analysis
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Datasets used in the analysis
Keyword
Tool Name
GSE59357
Gene Expression Omnibus
Dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines
7
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