Small molecules which reverse Methylphenidate treatment
Canned Analysis
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General Information
AccessionDCA00012947
TitleSmall molecules which reverse Methylphenidate treatment
DescriptionThe L1000 database was queried in order to identify small molecule perturbations which reverse the gene expression signature induced by Methylphenidate treatment in the Lymphoblastoid Cell Lines cell type.
Analysis URLhttp://amp.pharm.mssm.edu/L1000CDS2/#/result/58d1eb68e467bea600fb98a8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgswaminath
CREEDS IDdrug:3307
Cell TypeLymphoblastoid Cell Lines
Drug NameMethylphenidate
DrugBank IDDB00422
Organismhuman
PubChem CID4158
SMILES IDCOC(=O)C(C1CCCCN1)C2=CC=CC=C2
L1000CDS2 parameters
Directionreverse
Characteristic Direction parameters
Control SamplesGSM1277537, GSM1277538
Perturbed SamplesGSM1277539, GSM1277540
Tools used in the analysis
Dataset Accession
L1000CDS2
Published August 2016
An ultra-fast LINCS L1000 Characteristic Direction signature search engine
7756
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52889
Gene Expression Omnibus
Effect of methylphenidate on gene expression profiles of Attention Deficit Hyperactivity Disorder patients and unaffected controls.
7
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